Isosorbide is available in two forms: isosorbide mononitrate and isosorbide dinitrate.įDA Approved Indications for Isosorbide Dinitrate Isosorbide belongs to the nitrate group of medications that acts by releasing nitric oxide (N0), thereby causing vasodilation. This opinion changed after a few years, and now it gained worldwide acceptance. After introducing isosorbide, its popularity temporarily decreased as Needleman and his colleagues questioned its efficacy as it underwent extensive biotransformation in the liver. Isosorbide dinitrate was synthesized in the United States in the 1950s by Harris and colleagues. Porje initiated the research on isosorbide in Stockholm, and the drug was marketed in Sweden in 1946. Summarize the importance of collaboration and communication amongst the interprofessional team to enhance care delivery and improve outcomes for patients with angina pectoris receiving isosorbide.Review the appropriate monitoring necessary with isosorbide.Describe the potential adverse effects patients may experience when using isosorbide.Identify the mechanism of action of isosorbide.This activity will highlight the mechanism of action, adverse event profile, off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, and relevant interactions pertinent to the health care team members in managing patients with angina pectoris due to coronary artery disease and related conditions. This activity describes the indications, action, and contraindications for isosorbide as a valuable agent in treating angina pectoris due to coronary artery disease, heart failure with reduced ejection fraction, and achalasia. Isosorbide is a medication used to treat and prevent angina pectoris in patients with coronary heart disease.
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